OPTIMASI PENGGUNAAN HPMC DAN Na CMC PADA FORMULA TRANSDERMAL PATCH EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) DENGAN METODE SIMPLEX LATTICE DESIGN

Transdermal patch is drug delivery system that pasted through the skin. These preparations can provide a constant release, easy to use, reduce frequency of administration, eliminate first-pass metabolism, and side effects such as gastric irritation improve patient compliance. Blue pea (Clitoria ternatea L.) contains flavonoid compounds have anti-inflammatory activity. This study aims obtain optimal comparison HPMC Na CMC polymer in transdermal formula ethanol extract blue L.). Optimization was carried out using Simplex Lattice Design method with Software Expert version 11. The responses used included pH tests, weight thickness folding tests moisture content tests. obtained from verified SPSS program one sample t-test method. tested for acceptability determine whether it acceptable respondent or not. preparation 3.5%:1%, desirability value 0.944.